Candidate Embryos

embryo transfer

Equal amounts of research and consternation center on the proper cultivation, collection and treatment of oocytes during the IVF cycle. Only mature oocytes are a candidate for fertilization.  Moreover, only a minor percentage of fertilized eggs will be candidate embryos for transfer. And now of these candidate embryos, a fraction of them harbor normal genetics […]

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Maximizing Chances of Pregnancy 

maximize chance of pregnancy

Much emphasis in the field of reproductive technologies and IVF is placed on arriving at delivery of a healthy infant. Our goal is to promote generation of the healthiest, euploid (chromosomally-normal) embryo and transferring it to a primed, and accepting uterine cavity. Here it is anticipated to implant, develop and flourish until baby’s safe delivery. […]

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Revisiting Elective Single Embryo Transfer (eSET)

The transfer of a solitary embryo gains more support in North America. The idea is not new and was the focus of early IVF. Most often it has been applied to those patients with medical contraindications for multiple pregnancies. Ten years later, eSET (elective single embryo transfer) gains validity as a practice modicum in assisted […]

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Male Body Mass Index and Reproductive Potential

Because BMI can affect your chances of pregnancy and increase your chances of having a miscarriage, female BMI is considered when determining IVF treatment. Research is continually being done to define whether the negative affects of hormone alterations from obesity is on egg and/or embryo quality, sperm quality or responsiveness of the endometrium. Although an […]

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Recurrent Implantation Failure: Why Me?

Implantation of the embryos depends upon on a well-developing embryo and a synchronous healthy endometrium. It seems deceptively simple. However, for such success to manifest, a highly-organized and amazingly intricate web of molecular interactions must first occur. When pregnancy does not occur, our inclination is to look for both an answer and for a correction. […]

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Chronic Endometritis

Chronic endometritis is chronic inflammation (“itis”) of the endometrium (the uterine lining).  Chronic inflammation may hinder normal implantation of an embryo and its subsequent development. A patient with good embryo morphologic quality with either a negative pregnancy or with an early miscarriage may be evaluated for chronic endometritis before proceeding with further treatment. Evaluation of chronic […]

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What Makes a Good Endometrium and How is it Monitored?

Historically, we have been limited the means of assay endometrial receptivity.  It is a dynamic organ that needs to be evaluated  as such.  Embryo implantation occurs when the endometrial receptivity is precisely well orchestrated.  When the window of receptivity does not meet optimal implantation timing of the embryo, pregnancy will not occur. Endometrial biopsies where […]

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What About the Soil? Then Endometrium: An Unsung Hero

Much of our efforts in assisted reproductive technologies, namely IVF and IUI, is focused on cultivation of mature oocytes and generation of quality embryos.  However, without a rich environment, these embryos cannot exist. This soil is the endometrium, the lining of the uterus that is prepared monthly and then quickly shed like an afterthought, if […]

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Decoding the Menstrual Cycle

Menstruation, or the period, is the result of an endless dialogue between the command centers within the brain (the hypothalamus and pituitary gland); the ovary and the uterus. In particular the uterine lining, the endometrium, is responsive to the growth and maturation hormones provided by the ovary. The two major hormones responsible for preparing the […]

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Endometriosis and Infertility

Endometriosis and Fertility

Endometriosis is a common condition in women often associated with pain and infertility. It occurs when tissue that normally lines the inside of the uterus (endometrium) grows on the outside of it, mainly in the pelvis, ovaries and abdomen. Monthly hormonal changes can produce inflammation leading to pain and infertility due to the tissue itself […]

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