With the rapid rise of GLP-1 medications like Ozempic®, Wegovy®, Mounjaro™, and Zepbound™, more patients are entering fertility care while already taking these medications for weight loss, PCOS support, or metabolic health. Because weight and metabolic function play important roles in reproductive outcomes, it’s no surprise these medications are top of mind for many hopeful parents.

But one of the most common questions providers hear is:
“Can I continue my GLP-1 medication while going through IVF?”

Here’s what patients should know about safety, timing, and how to plan their IVF journey if they’ve been using GLP-1 medications.

What Are GLP-1 Medications?

GLP-1 receptor agonists and dual-incretin medications, such as Ozempic and Wegovy (semaglutide), or Mounjaro and Zepbound (tirzepatide), help regulate appetite, stabilize blood sugar, and support weight loss. They are widely used for:

• PCOS-related insulin resistance

• Pre-diabetes and type 2 diabetes

• Weight optimization prior to fertility treatment

• Improving metabolic health before pregnancy

These medications can indirectly support reproductive goals by improving ovulation regularity, reducing inflammation, and helping patients reach a healthier BMI before treatment.

But their use during active fertility treatment is another story.

Are GLP-1 Medications Safe to Use During IVF?

Short answer: No — they are not currently recommended during IVF or while trying to conceive.

Here’s why:

• There is limited human pregnancy safety data

• Animal studies show potential risks to fetal development

• GLP-1 medications remain in the system for an extended time

• Fertility specialists currently recommend a cautious, avoid-during-pregnancy approach

Most reproductive endocrinologists prefer that patients discontinue all GLP-1 medications well before ovarian stimulation or embryo transfer.

How Long Before IVF Should You Stop Ozempic, Wegovy, or Mounjaro?

Most fertility and metabolic specialists recommend stopping GLP-1 medications at least 2-3 months before attempting to conceive.

This allows time for:

• The medication to fully clear from your system

• Hormones and cycles to regulate

• Your body to adjust metabolically before IVF medications begin

Because every patient is different, timing may vary, but a 2-3 month washout is a widely accepted baseline.

Can GLP-1 Medications Improve IVF Success Before You Stop Them?

Yes, when used prior to the IVF process, GLP-1 medications can contribute positively to fertility outcomes.

Benefits may include:

• More regular menstrual cycles

• Improved insulin sensitivity

• Reduction in inflammatory markers

• Healthier ovulation patterns

• Weight loss, which is associated with improved IVF success in certain BMI categories

The key is stopping at the right time to ensure safety once pregnancy becomes possible.

What Happens If You Get Pregnant While Taking a GLP-1 Medication?

If you become pregnant while on a GLP-1:

1. Stop the medication immediately

2. Notify your fertility specialist or OB

3. Your provider will monitor the pregnancy closely

Current data is limited, but early registry information has not shown major risks, still, because research is ongoing, providers recommend discontinuation as soon as pregnancy is detected.

Do GLP-1 Medications Interact With IVF Medications?

GLP-1s do not directly interact with stimulation medications like gonadotropins. However, stopping a GLP-1 suddenly may temporarily affect:

• Cycle regularity

• Appetite and weight stability

• Metabolic shifts that influence hormone response

This is why coordinated planning between your fertility team and prescribing physician is essential.

FAQs: GLP-1 Medications & IVF

Can I restart my GLP-1 after embryo transfer?

No. GLP-1s should not be used during early pregnancy and are typically avoided throughout pregnancy and breastfeeding.

Do GLP-1s affect egg quality?

There is no evidence at this time they harm egg quality. In fact, metabolic improvements may indirectly help improve reproductive outcomes.

What if I’m taking a GLP-1 for diabetes, not weight loss?

Your prescribing doctor will help transition you to a pregnancy-safe alternative.

Will I gain weight after stopping the medication before IVF?

Some patients experience changes in appetite and weight. Planning nutrition, activity, and support can help maintain stability.

Is Mounjaro different from Ozempic for fertility?

Both require a washout period. Tirzepatide (Mounjaro) may have a slightly longer clearance time, so your provider may adjust the timing.

Key Takeaways Regarding GLP-1s and  Infertility Treatment

• GLP-1 medications can be highly useful before fertility treatment.

• They should be stopped prior to IVF and before attempting to conceive.

• Most specialists recommend a 2-3 month washout period.

• Coordination between your GLP-1 prescriber and fertility team ensures the safest and most effective planning.

• You can optimize metabolic health while still preparing safely for pregnancy.