Mother-Baby Complications in Older Women

Biologic Clock Ticks For All

First pregnancies in women over 35 years of age are the highest percentage since statistics have been kept. First pregnancies in women over age 40 have also never been higher and due to innovations in the Assisted Reproductive Technologies (A.R.T. such as IVF and Donor Egg) have enabled women to become pregnant well after traditional […]

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What Genetic Screening is Available After a Woman is Already Pregnant?

Previous FCNE blogs have reviewed genetic screening of embryos before they are implanted within the uterus; this is known as preimplantation genetic diagnosis or PGD.  What genetic screening is available after a woman is already pregnant and when are these recommended? New technology has recently permitted noninvasive prenatal testing for fetal chromosomal abnormalities from a […]

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Preimplantation Genetic Diagnosis

In addition to testing for single gene mutation abnormalities, preimplantation genetic diagnosis (PGD) is also used to detect a chromosomal abnormality when one partner has a balanced reciprocal translocation or a Robertsonian translocation. Chromosomes are string-like structures located in the nucleus of cells. Chromosomes contain genes that are made of DNA. All of our genetic […]

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Preimplantation Genetic Testing

preimplantation genetic diagnosis

In this five part series preimplantation genetic testing is defined and the categories of genetic disorders that preimplantation genetic testing may identify are described. Preimplantation genetic testing for diagnosis is referred to as PGD and is used to identify specific chromosomal or genetic defects in embryos created though in vitro fertilization (IVF) and intracytoplasmic sperm […]

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Recurrent Implantation Failure: Why Me?

Implantation of the embryos depends upon on a well-developing embryo and a synchronous healthy endometrium. It seems deceptively simple. However, for such success to manifest, a highly-organized and amazingly intricate web of molecular interactions must first occur. When pregnancy does not occur, our inclination is to look for both an answer and for a correction. […]

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Recurrent Pregnancy Loss: Genetic/Chromosomal

Approximately 60% to 70% of pregnancy losses whether as an isolated event (one) or recurrent (two or more)are numerically chromosomally abnormal. The most common chromosomal abnormality is Trisomy 16 which occurs in 26% of losses. Trisomy 16 is incompatible with life and has never been described progressing more than 11 weeks of gestation. The second […]

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