Vaginal yeast infections called vulvovaginal candidiasis is a common gynecologic malady affecting many women, especially those who are pregnant. The results from a recent study found that a common yeast infection medication is linked to miscarriage. The Journal, ‘Contemporary OB/GYN’ issued a clinical alert to all OB/GYN physicians warning of the risk of miscarriage in women taking an often prescribed medication to treat this condition during pregnancy. Fluconazole also known as Diflucan is customarily given in 150 mg increments to women suffering candidiasis. Unfortunately even low doses of fluconazole (<150 mg) may increase the chance of miscarriage. Dosages of 150 mg or greater was associated with a 2-3 X Risk of miscarriage. Using fluconazole during the first trimester of pregnancy was also associated with an 80% higher risk of neonatal cardiac closure defects (hole in the heart).
Fluconazole while safe to use when not pregnant, should not be used during pregnancy. Anti-fungal medications that are reported to be safe to use during pregnancy include Clotrimazole (Mycelx, Lotrimin) and Miconazole (Monistat). Topical preparations of azole for 7 days is the treatment of choice.
At Fertility Centers of New England, we recommend that patients consult with your doctor before taking any medication during pregnancy. If you have medication questions or have further questions about pregnancy, please contact us today!
For more information on medications and pregnancy, please check out the following additional blog posts: