July 15, 2015

Premature Ovarian Insufficiency

Premature Ovarian Insufficiency

Premature Ovarian Insufficiency (POI) formerly referred to as Premature Ovarian Failure (POF) is defined as the depletion of ovarian follicular activity before age 40 with menstrual disturbance, generally cessation, raised gonadotropin (FSH & LH) levels, and low estradiol levels. POI affects 1% of women. There are no proven therapeutic interventions to increase ovarian activity in these women. Women suspected of having POI should have a thorough evaluation for thyroid and adrenal function and a peripheral blood Karyotype (chromosome assessment).

POI may lead to complications affecting bone and cardiovascular health, sexual function and quality of life issues. These women should be under the care of a gynecologist familiar with the care and treatment of postmenopausal women and if pregnancy is desired they should be referred to a reproductive endocrinologist and infertility specialist to discuss the advisability of donor egg.

Donor egg is contraindicated in women with POI who also have Turner Syndrome. Pregnancy in a women with Turner Syndrome or Monosomy 6, (45,X) could be life threatening and should not be attempted unless cleared and under the care of a cardiologist with a special interest in adult congenital heart disease and a Maternal-Fetal-Medicine Specialist due to the high risk nature of pregnancy in these women.

If you think you are experiencing Premature Ovarian Insufficiency and need answers, please contact us for a free initial consult!


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Joseph A. Hill, III, M.D.

Joseph A. Hill, III, M.D. Board-Certified in Reproductive Endocrinology and Infertility