Is It Safe to Continue an Anti-Depressant In Pregnancy?

Patients often worry about the safety of anti-depressants and anti-anxiety medications in pregnancy and is it safe to continue an anti-depressant in pregnancy? Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used antidepressants in pregnancy. The available data on SSRIs is somewhat mixed. Some studies do show a very small increased risk of congenital malformations (particularly cardiac) when used in the first trimester. Other studies show no increased risk.  Regardless, SSRIs are generally considered relatively safe in pregnancy, as the risk of untreated depression often outweighs any potential risk associated with antidepressant treatment.

Taking Anxiety Medications During Pregnancy

Another class of drugs that comes into question are the benzodiazepines. Benzodiazepines are commonly used to treat anxiety outside of pregnancy. Some studies suggest a small increase in birth defects with benzodiazepine use during pregnancy, but others suggest that benzodiazepines are not teratogenic (meaning they do not appear to cause birth defects). While the risk of birth defects is questionable, benzodiazepines have been clearly linked to miscarriage and preterm birth, unfortunately. Additionally, chronic administration prior to delivery can cause neonatal toxicity and withdrawal. If a benzodiazepine is needed acutely during pregnancy, it should be used sparingly and only when absolutely necessary.

Is It Safe to Continue an Anti-Depressant In Pregnancy?

For any patient experiencing depression or anxiety, it is very important to stay connected with your mental health provider throughout pregnancy and the postpartum period. Pregnancy and post-pregnancy may be challenging for all patients from a mental health standpoint. The fatigue and hormonal shifts that occur may have a significant impact on anyone with or without a history of depression or anxiety. Ultimately, continuing or stopping medication is an individual decision. Staying in close communication with your mental health provider is incredibly important and will allow you to address any issues or concerns that may develop over the course of your pregnancy.

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Our physicians are experts in diagnosing fertility problems, and guiding our patients through the process with care and expertise. If you have more questions, please contact us. We are here to help.