January 18, 2019

ERA Helps Women With Repeated Implantation Failure

ERA Helps Women With Repeated Implantation Failure

Implantation of the embryo into the uterine endometrium is a highly precise, coordinated and orchestrated phenomenon. It is a symbiotic working between the embryo, as it is busily developing and its host for the next 9 months. Laying the foundation is critical to the success of the pregnancy. But what if the building permits were not quite validated yet? ERA helps women with repeated implantation failure.

In approximately 90% of women this precision is spot on. The protective coating of the endometrium dissolves for 24 hours at the precise time that the embryo is approximate to and ready for implantation. The implantation event requires the embryo to burrow into the endometrium and begin the cross-talk and the maternal interface to establish the placenta. That protective coating returns now covering the endometrium and the implanted embryo.

In approximately 10% of women, there may be an imprecision surrounding this implantation event. The embryo is ready for implantation but the endometrium is other premature or already spent. The window for implantation is not there and an otherwise fine candidate of an embryo degrades.

Hence, if there is a way to align the exact time the embryo is ready and the endometrium is accepting, the implantation event may be enhanced and pregnancy promoted. This theory and now practice is the basis of the endometrial receptivity assay.

Endometrial Receptivity Testing (ERA) may be indicated as an assessment of the endometrium in women with repeated implantation failure. The window of embryo implantation is a mere 24 hours and in the majority of women occurs on the 5th day after ovulation (or in FET cycles the morning after the 5th dose of progesterone) Day 6. ERA testing allows for the assessment of the endometrial gene-expression signature. It is a validated test that will define the window of implantation. Testing results will verify if the window is correct or define if the course of progesterone should be either prolonged or decreased.

The imprecision that may exists can be defined and cured. Already, this test has led to pregnancies and resultant babies in cases where many women would have ended their infertility journey.

If you would like to learn more about ERA and if this test is right for you, please contact us for a consultation!

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Danielle Vitiello, Ph.D., M.D. Board-Certified in Obstetrics and Gynecology, Reproductive Endocrinology and Infertility