In Vitro Fertilization (IVF)

Can Progesterone Prevent Miscarriage in the First Trimester?

Can Progesterone Prevent Miscarriage in the First Trimester?

First trimester bleeding is very common and very stressful. For decades, clinicians and researchers have looked for ways to prevent miscarriage and other pregnancy complications. A recent trial called the PREEMPT trial, investigated whether progesterone can prevent miscarriage in the first trimester. Specifically, whether vaginal progesterone supplementation could effectively prevent miscarriage or preterm delivery in patients with first-trimester vaginal bleeding.

Can Progesterone Prevent Miscarriage in the First Trimester?

This study was a multi-center, double-blind, randomized trial conducted between 2016 and 2020. Patients who presented with first-trimester vaginal bleeding were randomized to either vaginal progesterone or a placebo that was administered from the start of bleeding until 34 weeks gestation. Unfortunately, the outcomes were the same in both groups, and vaginal progesterone did not prevent miscarriage or preterm delivery.

Treatment for Patients With Recurrent Miscarriages

While vaginal progesterone may not be able to rescue a failing pregnancy, there are many other options for testing and treatment for patients with recurrent miscarriages. At Fertility Centers of New England, many patients come to us because they are struggling with infertility and/or miscarriages. We are proud to have helped thousands of patients realize their dream of becoming parents. While fertility treatment often feels like a marathon, the majority of patients will ultimately be successful. Our pregnancy rates remain outstanding, and we are very committed to delivering exemplary patient-centered care. If you have questions about your fertility or would like to set up a consultation, please contact us today.

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