Pre-Implantation Genetic Diagnosis Program
PGD is a technique used in conjunction with in vitro fertilization (IVF) to test embryos for either chromosomal abnormalities or inherited genetic diseases prior to uterine transfer and thus before the establishment of pregnancy. Using this technique, at risk couples can avoid the birth of an affected child and the potential, difficult decision to terminate a pregnancy. Download our PGD brochure for more information on PGD.
The top five reasons that PGD is used are:
- Single Gene Defect
- Translocation
- Aneuploidy for Repeat Pregnancy Loss (no infertility)
- Aneuploidy studies related to female age, for repeat failure (>38) and > 42 years in general
- Aneuploidy studies related to unexplained infertility, IVF failure (<38)
Results
Single gene defect, performed in conjunction with Marcus Hughes, MD, PhD:
44% delivery of normal, healthy children
Translocation, performed in conjunction with Santiago Munne, PhD:
33% delivery of healthy normal infants
Aneuploidy Screening performed in conjunction with Santiago Munne, PhD:
Recurrent Pregnancy Loss, women have had greater than or equal to 3 clinical losses, not infertile:
67% gestation greater than 15 weeks (versus 0% prior to PGD screening)
Age and Aneuploidy:
24% delivery (versus 0% prior to PGD)
Aneuploidy, less than 38 with repeat IVF failure:
10% delivery (versus 0% prior to screening)